Effects of diphenhydramine in the fetal lamb after maternal or fetal administration.

@article{Rurak1988EffectsOD,
  title={Effects of diphenhydramine in the fetal lamb after maternal or fetal administration.},
  author={Dan W Rurak and Sun Dong Yoo and Eddie Kwan and Stephen M. Taylor and Kenneth Wayne Riggs and J. E. Axelson},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1988},
  volume={247 1},
  pages={271-8}
}
The effects of diphenhydramine on fetal behavioral states, breathing activity, blood gas status, arterial pressure and heart rate have been investigated in the fetal lamb after maternal or fetal drug administration to steady state in chronically instrumented pregnant sheep. During maternal drug infusion there were declines in the percentage of low voltage electrocorticographic (ECoG) pattern 55-46%), the percentage of low voltage ECoG activity containing rapid eye movements (80-55%), the… CONTINUE READING
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