Effects of dihydropyridine receptor II-III loop peptides on Ca(2+) release in skinned skeletal muscle fibers.

@article{Lamb2000EffectsOD,
  title={Effects of dihydropyridine receptor II-III loop peptides on Ca(2+) release in skinned skeletal muscle fibers.},
  author={Graham D. Lamb and Roque El-Hayek and Noriaki Ikemoto and Dimitrie George Stephenson},
  journal={American journal of physiology. Cell physiology},
  year={2000},
  volume={279 4},
  pages={
          C891-905
        }
}
In skeletal muscle fibers, the intracellular loop between domains II and III of the alpha(1)-subunit of the dihydropyridine receptor (DHPR) may directly activate the adjacent Ca(2+) release channel in the sarcoplasmic reticulum. We examined the effects of synthetic peptide segments of this loop on Ca(2+) release in mechanically skinned skeletal muscle fibers with functional excitation-contraction coupling. In rat fibers at physiological Mg(2+) concentration ([Mg(2+)]; 1 mM), a 20-residue… CONTINUE READING

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