Effects of digoxin on isolated human peripheral arteries and veins.

  title={Effects of digoxin on isolated human peripheral arteries and veins.},
  author={Erich O. Mikkelsen and Karl Erik Andersson and Ole Lederballe Pedersen},
  journal={Acta pharmacologica et toxicologica},
  volume={45 4},
In isolated human crural arteries and veins, digoxin induced slowly developing, long-lasting contractions. These contractions were not diminished by alpha-adrenoceptor blockade or by washing, but were abolished by the calcium antagonist nifedipine. In the presence of digoxin, the maximum contractile responses to noradrenaline (18 microM) and potassium (127 mM) markedly increased, and the glycoside shifted the noradrenaline concentration-response curve to the left. Immersion of vein preparations… 

Effects of digoxin on islated human mesenteric vessels.

It is concluded that digoxin contracts mesenteric vessels by a direct action on the muscle cells, and potentiates the contractant effects of noradrenaline, and these effects are dependent on the availability of extracellular calcium.

Effects of digoxin in isolated human pulmonary vessels.

  • E. Mikkelsen
  • Biology, Medicine
    Acta pharmacologica et toxicologica
  • 1979
It is concluded that digoxin increases the tension in pulmonary arteries and veins, and increases the maximum response to noradrenaline and potassium in both types of vessels.

Neurogenic component of ouabain-evoked contractions is modulated by the endothelium.

The results suggest that the endothelium modulates the neurogenic component involved in contractions evoked by the glycoside by a diffusible factor (or factors) whose nature is unknown; however, the factor is neither nitric oxide nor a cyclooxygenase-related compound.

Potentiating and Depressive Effects of Ouabain and Potassium‐Free Solutions on Rat Mesenteric Resistance Vessels

The results indicate that ouabain and K-free solutions can have both short-term potentiating and long-term depressive effects on the mechanical response of rat mesenteric resistance vessels to norepinephrine.

Endothelial role in ouabain-induced contractions in guinea pig carotid arteries.

The results suggest the existence of an inhibitory modulation by the endothelium of contractions induced by ouabain, likely mediated by a diffusible factor (or factors) released from these cells.

Effects of ouabain on isolated cerebral and femoral arteries of the cat: a functional and biochemical study

Results indicate that ouabain‐induced contraction of cerebral arteries is due to a direct effect on vascular smooth muscle cells, while in femoral arteries it isDue to noradrenaline release from adrenergic nerve terminals; and the electrogenic Na+ pump activity is greater in cerebral than in peripheral arteries.

Extracardiac and coronary vascular effects of digitalis.

The local effects of systemic digoxin on the cutaneous microcirculation

It reduces resting heart rate, blood pressure and baseline cutaneous blood flow and augments the vasoconstrictive effect of exogenous norepinephrine and does not support the hypothesis that digoxin lowers diastolic blood pressure through a direct action on blood vessels.

Control of Arteriolar Resistance in Heart Failure: Partial Attenuation of Specific Phosphodiesterase Inhibitor‐Mediated Vasodilation by Digitalis Glycosides

Although local administration of digoxin did not significantly alter baseline vascular tone in patients with CHF, it substantially decreased the direct vasodilatory effect induced by specific type III phosphodiesterase with amrinone.



The effect of nifedipine on isolated human peripheral vessels.

Isometric tension was recorded in ring preparations of human peripherial arteries and veins contracted by potassium (127mM) and noradrenaline (1.8 X 10(-5)M). In the veins, nifedipine had a marked

The neurogenic vasoconstrictor effect of digitalis on coronary vascular resistance.

There is a coronary vasoconstrictor effect of intravenous acetylstrophanthidin and digoxin, of rapid onset, which is mediated through alpha adrenergic receptor stimulation.

Contractile responses of isolated rabbit aortae to transmural stimulation as affected by calcium, strontium, sodium and ouabain.

  • N. Toda
  • Biology
    Japanese journal of pharmacology
  • 1972
The present study was an investigation into the effects of ions and drugs that interact with Ca++ on the resting tension of the vascular smooth muscle and on its contractile response to electrical transmural stimulation and exogenous noradrenaline.

Regional Hemodynamic Effects of a Digitalis Glycoside in the Conscious Dog with and without Experimental Heart Failure

In the normal conscious dog, ouabain causes vasoconstriction in the regional vascular beds, apparently by its direct vascular action, and, in addition, a cholinergically mediated vasodilatation in the mesenteric bed.

Effect of dihydro-ouabain on vascular tone on the perfused cannine hindlimb.

It is shown that dihydro-ouabain causes contraction of vascular smooth muscle by an adrenergic mechanism and increasing doses of this drug produced significant dose-dependent increases in perfusion pressure.

Effects of Acetylstrophanthidin on Isolated Veins of the Dog

In addition to its direct constrictor action on cutaneous and mesenteric veins, acetylstrophanthidin sensitized cutaneous veins to vasoactive agents and to changes in ionic environment.


The present investigation was undertaken to characterize the effects of ouabain on a specific vascular bed, that of the forearm, which was examined in normal subjects and in patients with congestive heart failure.

Studies on digitalis. II. Extracardiac effects on venous return and on the capacity of the peripheral vascular bed.

A preparation was developed which permitted characterization of the effects of digitalis on the capacity of the peripheral vascular bed and on venous return and it is clear that digitalis glycosides act directly on the peripheral circulation of both dog and man.

Relationship between noradrenaline-induced depolarization and contraction in vascular smooth muscle.

The results suggest that the magnitude of the noradrenaline-induced contraction is related to the height of the membrane potential and not to the degree of depolarization produced by the adrenergic transmitter.

The Mechanism of K‐Induced Vasodilation of the Coronary Vascular Bed of the Dog

The data do support the hypothesis that K+-induced vasodilation is at least partly the result of an activation of the electrogenic Na +—K+- transport system of coronary smooth muscle.