Effects of differing durations of antecedent hypoglycemia on counterregulatory responses to subsequent hypoglycemia in normal humans.

@article{Davis2000EffectsOD,
  title={Effects of differing durations of antecedent hypoglycemia on counterregulatory responses to subsequent hypoglycemia in normal humans.},
  author={Stephen Neil Davis and Stephnie Mann and Pietro Renato Galassetti and Ray Anthony Neill and Donna Bowman Tate and Andrew C. Ertl and Fernando Costa},
  journal={Diabetes},
  year={2000},
  volume={49 11},
  pages={1897-903}
}
The aim of this study was to determine whether the duration of antecedent hypoglycemia regulates the magnitude of subsequent counterregulatory failure. A total of 31 lean healthy overnight-fasted individuals (16 men/15 women) were studied. There were 15 subjects (8 men/7 women) who underwent two separate 2-day randomized experiments separated by at least 2 months. On day 1, 2-h hyperinsulinemic (9 pmol x kg(-1) x min(-1)) euglycemic (5.2 +/- 0.1 mmol/l) or hypoglycemic (2.9 +/- 0.1 mmol/l… CONTINUE READING

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