Effects of differing dosages of vigabatrin (Sabril) on cognitive abilities and quality of life in epilepsy.

@article{Dodrill1995EffectsOD,
  title={Effects of differing dosages of vigabatrin (Sabril) on cognitive abilities and quality of life in epilepsy.},
  author={Carl B. Dodrill and John L Arnett and Kenneth W. Sommerville and Nan M. Sussman},
  journal={Epilepsia},
  year={1995},
  volume={36 2},
  pages={164-73}
}
Vigabatrin (VGB) prevents seizures by irreversible inhibition of gamma-aminobutyric acid (GABA) transaminase and a resulting increase in GABA levels. We evaluated the cognitive and quality-of-life (QOL) effects of VGB in a double-blinded, add-on, placebo-controlled, parallel group dose-response study of patients with focal epilepsy whose complex partial seizures (CPS) were difficult to control. In a single investigation, patients were randomly assigned to placebo (n = 40), 1 g VGB (n = 36), 3 g… CONTINUE READING

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