Effects of different types of diet and sodium saccharin on proliferation at the limiting ridge of the rat forestomach.

@article{Masui1990EffectsOD,
  title={Effects of different types of diet and sodium saccharin on proliferation at the limiting ridge of the rat forestomach.},
  author={Tohru Masui and Emily M. Garland and Ching Yung Wang and Samuel M Cohen},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1990},
  volume={28 7},
  pages={497-505}
}
Sodium saccharin, at high doses in the diet, has been reported to cause hyperplasia of the forestomach (squamous portion of stomach), at the limiting ridge in F344 rats, in addition to its potential to induce proliferative effects on the urinary bladder epithelium. We have characterized this hyperplasia of the squamous epithelium of the forestomach at the limiting ridge in F344 and Sprague-Dawley rats given various doses of sodium saccharin for 4 to 95 wk. With increasing doses of sodium… CONTINUE READING