Effects of different polyunsaturated fatty acids on growth-related early gene expression and cell growth.

@article{Sellmayer1996EffectsOD,
  title={Effects of different polyunsaturated fatty acids on growth-related early gene expression and cell growth.},
  author={Alois Sellmayer and Ulrich Danesch and Peter C. Weber},
  journal={Lipids},
  year={1996},
  volume={31 Suppl},
  pages={S37-40}
}
Effects of polyunsaturated fatty acids on expression of early-response genes c-fos and Egr-1 and induction of cell growth were assessed in Swiss 3T3 fibroblasts. Stimulation with arachidonic acid increased mRNA levels of c-fos and Egr-1. This effect was inhibited by preincubation with cyclooxygenase inhibitors and restored by addition of prostaglandin E2 (PGE2), the predominant eicosanoid produced in Swiss 3T3 fibroblasts. Further signaling of PGE2, was mediated by a protein kinase C-dependent… CONTINUE READING

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