Effects of different omega-3 sources, fish oil, krill oil, and green-lipped mussel against cytokine-mediated canine cartilage degradation

@article{Buddhachat2016EffectsOD,
  title={Effects of different omega-3 sources, fish oil, krill oil, and green-lipped mussel against cytokine-mediated canine cartilage degradation},
  author={Kittisak Buddhachat and Puntita Siengdee and Siriwadee Chomdej and Kumpanart Soontornvipart and Korakot Nganvongpanit},
  journal={In Vitro Cellular \& Developmental Biology - Animal},
  year={2016},
  volume={53},
  pages={448-457}
}
Our purpose was to evaluate the protective effect of three marine omega-3 sources, fish oil (FO), krill oil (KO), and green-lipped mussel (GLM) against cartilage degradation. Canine cartilage explants were stimulated with either 10 ng/mL interleukin-1β (IL-1β) or IL-1β/oncostatin M (10 ng/mL each) and then treated with various concentrations of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA; 3 and 30 μg/mL), FO, KO, or GLM (250, 500, and 1000 μg/mL) for 28 days. Gene expression was then… 
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Comment on “Effects of different omega-3 sources, fish oil, krill oil, and green-lipped mussel against cytokine-mediated canine cartilage degradation” In Vitro Cell Dev Biol Anim. 2017 doi: 10.1007/s11626-016-0125-y.
  • S. Myers, C. Oliver
  • Biology, Medicine
    In Vitro Cellular & Developmental Biology - Animal
  • 2017
TLDR
The results and conclusions the authors have reached are not valid and further work attempting to elucidate mechanisms of action and the effects of Antinol on cartilage degradation are warranted.
Response to comments on “Effects of different omega-3 sources, fish oil, krill oil, and green-lipped mussel, against cytokine-mediated canine cartilage degradation”—In Vitro Cell Dev Biol Anim. 2017 doi: 10.1007/s11626-016-0125-y
TLDR
From the findings, three omega-3 sources (fish oil, krill oil, and AGO) exhibited a possible mechanism for preventing the inflammation of chondrocytes from interleukin-1β (Buddhachat et al. 2017), but AGO seemed to be less effective in this regard compared with the others.
Effectiveness of a combined New Zealand green-lipped mussel and Antarctic krill oil supplement on markers of exercise-induced muscle damage and inflammation in untrained men
TLDR
ESO-572®, a combination of green-lipped mussel and krill oil, is used in mitigating the deleterious effects of EIMD and was superior to PCSO-524® in protecting against the loss in joint ROM during recovery.
Effectiveness of a combined New Zealand green-lipped mussel and Antarctic krill oil supplement on markers of exercise-induced muscle damage and inflammation in untrained men.
TLDR
ESO-572®, a combination of green-lipped mussel and krill oil, is 'at least as good' as PCSO-524® in reducing markers of muscle damage and soreness following eccentric exercise and was superior in protecting against the loss in joint ROM during recovery.
Health benefits of dietary marine DHA/EPA-enriched glycerophospholipids.
Potential modulatory mechanisms of action by long-chain polyunsaturated fatty acids on bone cell and chondrocyte metabolism.
Low levels of very-long-chain n-3 PUFA in Atlantic salmon (Salmo salar) diet reduce fish robustness under challenging conditions in sea cages
TLDR
10 g/kg EPA + DHA in the Atlantic salmon diet, a level previously regarded as sufficient, was found to be too low to maintain fish health under demanding environmental conditions in sea cages.
Fatty Acids and Oxylipins in Osteoarthritis and Rheumatoid Arthritis—a Complex Field with Significant Potential for Future Treatments
TLDR
Alterations in FA profiles and their potential implications in SPM production may affect joint lubrication, synovial inflammation, pannus formation, as well as cartilage and bone degradation and contribute to the pathogeneses of inflammatory joint diseases.
Importance of the Role of ω-3 and ω-6 Polyunsaturated Fatty Acids in the Progression of Brain Cancer
TLDR
The current understanding of the role of PUFAs and its metabolites (oxylipins) in different brain tumors, proliferation, apoptosis, invasion, angiogenesis, and immunosuppression is highlighted by focusing on recent research in vitro and in vivo.
Effect of an Oral Joint Supplement When Compared to Carprofen in the Management of Hip Osteoarthritis in Working Dogs.
TLDR
The oral joint supplement and carprofen produced some improvements in individual scores but where unable to do so when overall results were considered, suggesting each of these options may not be able to fully address the demands of a working dog with joint disease and related pain.
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