Effects of different cyclodextrins on the morphology, loading and release properties of poly (DL-lactide-co-glycolide)-microparticles containing the hypnotic agent etizolam

  title={Effects of different cyclodextrins on the morphology, loading and release properties of poly (DL-lactide-co-glycolide)-microparticles containing the hypnotic agent etizolam},
  author={A. Lopedota and A. Cutrignelli and A. Trapani and G. Boghetich and N. Denora and V. Laquintana and G. Trapani and G. Liso},
  journal={Journal of Microencapsulation},
  pages={214 - 224}
  • A. Lopedota, A. Cutrignelli, +5 authors G. Liso
  • Published 2007
  • Materials Science, Medicine
  • Journal of Microencapsulation
  • The aim of this study was to gain insight into the feasibility of using microparticles (MPs) constituted by the biodegradable poly (DL-lactide-co-glycolide) (PLGA) and a number of cyclodextrins (CDs) as an orally sustained delivery system of the hypnotic agent etizolam (ETZ). A further aim of the work was to investigate the effects of different CDs on the morphology, loading, and release properties of the MPs prepared. For these purposes, ETZ alone, and ETZ/CD-PLGA loaded MPs were prepared by… CONTINUE READING
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