Effects of diethylstilbestrol on programmed oocyte death and induction of polyovular follicles in neonatal mouse ovaries.

@article{Kim2009EffectsOD,
  title={Effects of diethylstilbestrol on programmed oocyte death and induction of polyovular follicles in neonatal mouse ovaries.},
  author={Hannah J Kim and Tadaaki Nakajima and Shinji Hayashi and Pierre Chambon and Hajime Watanabe and Taisen Iguchi and Tomomi Sato},
  journal={Biology of reproduction},
  year={2009},
  volume={81 5},
  pages={1002-9}
}
In mice, neonatal exposure to a synthetic estrogen, diethylstilbestrol (DES), induces polyovular follicles, which contain two or more oocytes per ovarian follicle. We reported previously that the estrogen receptor beta (ESR2) mediates DES signaling in polyovular follicle induction. However, the specific mechanism of polyovular follicle induction has not yet been clarified. Folliculogenesis in rodents begins soon after birth, accompanied by programmed oocyte death and germ cell loss. In this… CONTINUE READING