Effects of diethyl maleate on non-protein sulfhydryl content and cellular functions of mouse thymocytes in vitro.


The electrophilic compound diethyl maleate (DEM, 10(-5)-10(-3) M) decreased the content of non-protein sulfhydryl groups in mouse thymocytes in vitro and affected mitotic activity, spontaneous migration and viability of the cells. The mitotic activity of mouse thymocytes was most sensitive to DEM. It is probable that the decrease of the cell content of… (More)


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