Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan.

@article{Vogt2008EffectsOD,
  title={Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan.},
  author={Liffert Vogt and Femke Waanders and Frans Boomsma and Dick de Zeeuw and Gerjan Navis},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2008},
  volume={19 5},
  pages={999-1007}
}
There is large interindividual variability in the antiproteinuric response to blockade of the renin-angiotensin-aldosterone system (RAAS). A low-sodium diet or addition of diuretics enhances the effects of RAAS blockade on proteinuria and BP, but the efficacy of the combination of these interventions is unknown. Therefore, this randomized, double-blind, placebo-controlled trial to determine the separate and combined effects of a low-sodium diet and hydrochlorothiazide (HCT) on proteinuria and… CONTINUE READING
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