Effects of dietary selenium and vitamin E on covalent binding of aflatoxin to chick liver cell macromolecules.

@article{Chen1982EffectsOD,
  title={Effects of dietary selenium and vitamin E on covalent binding of aflatoxin to chick liver cell macromolecules.},
  author={Jin-ping Chen and M P Goetchius and Gerald F. Combs and Thomas Colin Campbell},
  journal={The Journal of nutrition},
  year={1982},
  volume={112 2},
  pages={
          350-5
        }
}
Day-old single comb white Leghorn chicks of both sexes maternally depleted in selenium (Se) and vitamin E (VE) were fed a low Se and VE-free semipurified basal diet or that diet supplemented with graded levels of Se (0.2 - 20.0 ppm as Na2SeO3) of VE (100 IU/g as all-rac-alpha-tocopheryl acetate), or both. At 14 days of age, chicks were given 1 mg/kg [3H] aflatoxin B1 (AFB1) i.p. and killed either 2 or 24 hours later. Covalent binding of AFB1 to liver DNA and RNA in chicks fed the basal diet was… CONTINUE READING
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