Effects of dietary oxidized tyrosine products on insulin secretion via the thyroid hormone T3-regulated TRβ1–Akt–mTOR pathway in the pancreas

@article{Ding2017EffectsOD,
  title={Effects of dietary oxidized tyrosine products on insulin secretion via the thyroid hormone T3-regulated TR$\beta$1–Akt–mTOR pathway in the pancreas},
  author={Yinyi Ding and Xue Tang and Xiang-Rong Cheng and Fang-fang Wang and Zhuokun Li and Shan Wu and Xi Kou and Yong-hui Shi and G. Le},
  journal={RSC Advances},
  year={2017},
  volume={7},
  pages={54610-54625}
}
Oxidized tyrosine products (OTPs) have been detected in commercial foods with high protein content. Dityrosine (Dityr) is a typical oxidized tyrosine product. The previous studies in our lab demonstrated that dityrosine administration impaired glucose tolerance and suppressed the bio-function of thyroid hormone T3 of mice. The T3-activated Akt–mTOR signaling pathway plays important roles in insulin synthesis in pancreatic β cells. Due to the structural homology between dityrosine and T3, the… Expand
4 Citations
Dityrosine suppresses the cytoprotective action of thyroid hormone T3viainhibiting thyroid hormone receptor-mediated transcriptional activation
Dityrosine (Dityr) is the most common oxidized form of tyrosine. In the previous studies of mice treated with dityrosine, cell death in the pancreas, kidneys, and liver was detected in the presenceExpand
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