Effects of dietary oxidized tyrosine products on insulin secretion via the thyroid hormone T3-regulated TRβ1–Akt–mTOR pathway in the pancreas

  title={Effects of dietary oxidized tyrosine products on insulin secretion via the thyroid hormone T3-regulated TR$\beta$1–Akt–mTOR pathway in the pancreas},
  author={Yinyi Ding and Xue Tang and Xiang-Rong Cheng and Fang-fang Wang and Zhuokun Li and Shan Wu and Xi Kou and Yong-hui Shi and G. Le},
  journal={RSC Advances},
Oxidized tyrosine products (OTPs) have been detected in commercial foods with high protein content. Dityrosine (Dityr) is a typical oxidized tyrosine product. The previous studies in our lab demonstrated that dityrosine administration impaired glucose tolerance and suppressed the bio-function of thyroid hormone T3 of mice. The T3-activated Akt–mTOR signaling pathway plays important roles in insulin synthesis in pancreatic β cells. Due to the structural homology between dityrosine and T3, the… Expand
4 Citations
Dityrosine suppresses the cytoprotective action of thyroid hormone T3viainhibiting thyroid hormone receptor-mediated transcriptional activation
Dityrosine (Dityr) is the most common oxidized form of tyrosine. In the previous studies of mice treated with dityrosine, cell death in the pancreas, kidneys, and liver was detected in the presenceExpand
Intake of Oxidized Proteins and Amino Acids and Causative Oxidative Stress and Disease: Recent Scientific Evidences and Hypotheses.
The present review collects the most recent evidences of the health risks of dietary protein oxidation and proposes reasonable hypotheses and future perspectives on the field. Expand
Urinary Metabolomic Markers of Protein Glycation, Oxidation, and Nitration in Early-Stage Decline in Metabolic, Vascular, and Renal Health
Measurement of urinary glycated, oxidized, crosslinked, and branched-chain amino acids provides the basis for a noninvasive health screen for early-stage health decline in metabolic, vascular, and renal health. Expand
Processing milk causes the formation of protein oxidation products which impair spatial learning and memory in rats
This study explored the effects of protein oxidation during milk processing on spatial learning and memory in rats. Increasing the heating time, fat content, and inlet air temperature duringExpand


Effect of dietary oxidized tyrosine products on insulin secretion via the oxidative stress-induced mitochondria damage in mice pancreas
Oxidized tyrosine products (OTPs) have been detected in commercial food and have been demonstrated to induce oxidative damage in vivo. The pancreas plays an important role in glucose metabolism, butExpand
Dityrosine administration induces dysfunction of insulin secretion accompanied by diminished thyroid hormones T3 function in pancreas of mice
The data suggest that Dityr suppress T3-regulated insulin synthesis stimulated by glucose via an indirect way of decreasing sensibility to T3 in pancreas, which indicates thatDityr can disrupt THs function in Pancreas leading to glucose metabolism disorder. Expand
Dietary oxidized tyrosine (O-Tyr) stimulates TGF-β1-induced extracellular matrix production via the JNK/p38 signaling pathway in rat kidneys
The results suggest that dietary O-Tyr could induce oxidative stress, inflammation and renal fibrosis through JNK/p38/TGF-β1 signaling pathway, and Dityr (accounting for 22 % of the total O- tyr material) may be responsible for the O- Tyr-induced injury. Expand
Health Effects of Dietary Oxidized Tyrosine and Dityrosine Administration in Mice with Nutrimetabolomic Strategies.
O-Tyr and Dityr exposure changed many systemic metabolic processes, including reduced choline bioavailability, led to fat accumulation in liver, induced hepatic injury, and renal dysfunction, resulted in changes in gut microbiota functions, elevated risk factor for cardiovascular disease, altered amino acid metabolism, and inhibited energy metabolism. Expand
The TRβ1 is essential in mediating T3 action on Akt pathway in human pancreatic insulinoma cells
It is demonstrated that the β1 receptor mediates the T3 upregulation of protein synthesis and cell size, together with the cell proliferation and survival, playing a crucial role in the T2 regulation of the PI3K/Akt pathway. Expand
Thyroid Hormone Stimulates Protein Synthesis in the Cardiomyocyte by Activating the Akt-mTOR and p70S6K Pathways*
Rapid T3-mediated activation of PI3K by cytosolic TRα1 and subsequent activation of the Akt-mTOR-S6K signaling pathway may underlie one of the mechanisms by which thyroid hormone regulates physiological cardiac growth. Expand
Activation of PPARδ up-regulates the expression of insulin gene transcription factor MafA and ameliorates glucose-induced insulin secretion impaired by palmitate
Results demonstrate that activation of PPARδ improves insulin secretion impaired by palmitate and plays a role in the JNK–MafA–GLUT2 pathway. Expand
Potential contribution of translational factors to triiodo-L-thyronine-induced insulin synthesis by pancreatic beta cells.
It was found that, in parallel with increased insulin generation, T3 induced p70S6K phosphorylation and the expression of the translational factors eIF2, eIF5A, and eukaryotic elongation factor 1 alpha (eEF1A). Expand
Overexpression of protein tyrosine phosphatase 1B impairs glucose-stimulated insulin secretion in INS-1 cells.
It is suggested that overexpression of PTP1B can inhibit GSIS in INS-1 cells through negatively regulating insulin signaling. Expand
Oxidized casein impairs antioxidant defense system and induces hepatic and renal injury in mice.
  • Z. Li, Ling Mo, G. Le, Yong-hui Shi
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2014
Oxidized casein impairs antioxidant defense system and induces hepatic and renal fibrosis in mice liver and kidney after oxidizing casein feeding. Expand