Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: in vivo and in vitro studies.

@article{Billman2010EffectsOD,
  title={Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: in vivo and in vitro studies.},
  author={George E. Billman and Yoshinori Nishijima and Andriy E Belevych and Dmitry Terentyev and Ying Xu and Kaylan M. Haizlip and Michelle M. Monasky and Nitisha Hiranandani and William S. Harris and S{\'a}ndor Gyorke and Cynthia A. Carnes and Paul M. L. Janssen},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2010},
  volume={298 4},
  pages={H1219-28}
}
Since omega-3 polyunsaturated fatty acids (n-3 PUFAs) can alter ventricular myocyte calcium handling, these fatty acids could adversely affect cardiac contractile function, particularly following myocardial infarction. Therefore, 4 wk after myocardial infarction, dogs were randomly assigned to either placebo (corn oil, 1 g/day, n = 16) or n-3 PUFAs supplement [docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA) ethyl esters; 1, 2, or 4 g/day; n = 7, 8, and 12, respectively] groups. In vivo… CONTINUE READING

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Omega–3 polyunsaturated fatty acids—modulation of voltage-dependent L-type Ca2 current in H1227 OMEGA–3 FATTY ACIDS DO NOT ALTER VENTRICULAR FUNCTION AJP-Heart

  • H Hazama, T Nakajima, +7 authors Y. Okuda
  • Circ Physiol • VOL
  • 2010
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