Effects of dietary aluminum excess and manganese deficiency on neurobehavioral endpoints in adult mice.

@article{Golub1992EffectsOD,
  title={Effects of dietary aluminum excess and manganese deficiency on neurobehavioral endpoints in adult mice.},
  author={M. Golub and Bin Han and Carl L. Keen and M Eric Gershwin},
  journal={Toxicology and applied pharmacology},
  year={1992},
  volume={112 1},
  pages={154-60}
}
Studies in mice have suggested that both dietary Al excess and dietary Mn deficiency promote oxidative tissue damage. To determine if these factors can interact to produce functional nervous system damage, female mice (N = 10-12 per group) were fed diets with control or low Mn (35 or 3 micrograms Mn/g diet) and/or control or high Al (25 or 1000 micrograms Al/g diet, Al as Al lactate) content for a 90-day period. No overt signs of neurotoxicity were observed in any group. Excess Al produced a… CONTINUE READING
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