Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome.

@article{Biddinger2005EffectsOD,
  title={Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome.},
  author={Sudha B Biddinger and Katrine Almind and Makoto Miyazaki and Efi G Kokkotou and James M. Ntambi and C Ronald Kahn},
  journal={Diabetes},
  year={2005},
  volume={54 5},
  pages={1314-23}
}
Both environmental and genetic factors play important roles in the development of the metabolic syndrome. To elucidate how these factors interact under normal conditions, C57Bl/6 (B6) and 129S6/SvEvTac (129) mice were placed on a low-fat or high-fat diet. Over 18 weeks, the 129 strain developed features of the metabolic syndrome, notably obesity… CONTINUE READING