Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain

@article{Snigdha2012EffectsOD,
  title={Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain},
  author={Shikha Snigdha and Giuseppe Astarita and Daniele Piomelli and Carl Cotman},
  journal={Neuroscience},
  year={2012},
  volume={202},
  pages={326-333}
}
Despite several recent studies suggesting that dysregulation of brain lipid metabolism might contribute to the mechanisms of aging and Alzheimer's disease (AD), lipid metabolism has not been evaluated extensively in the aging brain. Here, we use a lipidomic approach to demonstrate that antioxidants plus mitochondrial cofactors treatment, either alone or in combination with behavioral enrichment, attenuates lipid abnormalities in the frontal cortices of aged canine in a manner correlated with… CONTINUE READING
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