Effects of diesel exhaust particles on antigen-presenting cells and antigen-specific Th immunity in mice.

@article{Inoue2009EffectsOD,
  title={Effects of diesel exhaust particles on antigen-presenting cells and antigen-specific Th immunity in mice.},
  author={Ken-ichiro Inoue and Eiko Koike and Hirohisa Takano and Rie Yanagisawa and Takamichi Ichinose and Toshikazu Yoshikawa},
  journal={Experimental biology and medicine},
  year={2009},
  volume={234 2},
  pages={200-9}
}
Diesel exhaust particles (DEP) exacerbate antigen-related airway inflammation and hyperresponsiveness in mice; however, the mechanisms remain undefined. The present study characterized more precisely which pathways and cellular events of the allergic response are amplified by DEP in view of the maturation/activation/function of antigen-presenting cells (APC) and the antigen-specific Th response. We evaluated the effects of DEP on the phenotype and function of bone marrow-derived dendritic cells… CONTINUE READING