Effects of dichlobenil on ultrastructural morphology and cell replication in the mouse olfactory mucosa.

@article{Mancuso1997EffectsOD,
  title={Effects of dichlobenil on ultrastructural morphology and cell replication in the mouse olfactory mucosa.},
  author={Maria Rosaria Mancuso and Anna Giovanetti and Eva B. Brittebo},
  journal={Toxicologic pathology},
  year={1997},
  volume={25 2},
  pages={
          186-94
        }
}
The herbicide dichlobenil (2,6-dichlorobenzonitrile) is a tissue-specific inducing necrosis in the olfactory mucosa. Transmission electron microscopy showed vacuolations (1 hr) and necrosis (4 hr) in the Bowman's glands following intraperitoneal injection of dichlobenil (25 mg/kg) in C57B1 mice, whereas no lesions were noted in the olfactory neuroepithelium at these timepoints. Twenty-four hr following injection (25 mg/kg), most of the propria and the olfactory epithelium were severely damaged… CONTINUE READING

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