Effects of dibutyryl adenosine 3',5'-cyclic monophosphate on human melanocytes in vitro.

@article{Kitano1976EffectsOD,
  title={Effects of dibutyryl adenosine 3',5'-cyclic monophosphate on human melanocytes in vitro.},
  author={Yukiko Kitano},
  journal={Acta dermato-venereologica},
  year={1976},
  volume={56 3},
  pages={223-8}
}
The effects of cyclic AMP and its analogue, dibutyryl cyclic AMP (DBcAMP) on the pigmentary system were studied by using human epidermal melanocytes in culture. The melanocytes responded to 1 mM DBcAMP with an increase in number, length, and complexity of dendritic processes. The effect of DBcAMP on the dendritogenesis was reversible. Melanin synthesis, as indicated by the uptake of tyrosine in the presence of an inhibitor of protein synthesis, was significantly stimulated by DBcAMP. The… CONTINUE READING

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