Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi

@article{SoutoPadrn2006EffectsOD,
  title={Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi},
  author={Thais Cristina Souto-Padr{\'o}n and Ana Paula C A Lima and Rachel Oliveira Ribeiro},
  journal={Parasitology Research},
  year={2006},
  volume={99},
  pages={317-320}
}
Although local anesthetics (LA) are considered primarily Na+-channel blockers in the past decade, an alternative action of LA as inhibitors of fusion among compartments of the endocytic/exocytic pathways was described. In epimastigote forms of Trypanosoma cruzi, we observed that 50 mM dibucaine reduced the rates of uptake of bovine serum albumin (BSA) and immunoglobulin to 60% of control values in addition to the delay of exocytosis of cysteine proteases. Fusion among endocytic compartments was… Expand
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