Effects of diabetes on oxidative decarboxylation of branched-chain keto acids.

  title={Effects of diabetes on oxidative decarboxylation of branched-chain keto acids.},
  author={M. May and V. Mancusi and R. Aftring and M. Buse},
  journal={The American journal of physiology},
  volume={239 3},
  • M. May, V. Mancusi, +1 author M. Buse
  • Published 1980
  • Chemistry, Medicine
  • The American journal of physiology
  • Oxidative decarboxylation is the first irreversible step in the degradation of leucine. The effect of streptozotocin diabetes on this reaction was studied in cell-free rat liver preparations, using [1-14C]alpha-ketoisocaproate as substrate. Diabetes increased the branched-chain ketoacid dehydrogenase (BCKD) activity (per g liver or per mg protein) of homogenates, but the ratios of homogenate BCKD activity to other mitochondrial markers remained unchanged. A cytosolic branched-chain ketoacid… CONTINUE READING
    17 Citations
    Catabolism of branched-chain amino acids by diaphragm muscles of fasted and diabetic rats.
    • 25
    Ethanol and leucine oxidation--II. Leucine oxidation by rat tissue in vitro.
    • 15
    Acute effects of acidosis on protein and amino acid metabolism in perfused rat liver
    • 6


    Purification and characterization of branched chain alpha-keto acid dehydrogenase complex of bovine kidney.
    • 185
    • PDF
    Leucine degradation in cell-free extracts of skeletal muscle.
    • 117
    Branched chain 2‐oxo‐acid dehydrogenase complex of rat liver
    • 46
    Branched-chain amino acid oxidation by isolated rat tissue preparations.
    • 160