Effects of diabetes on oxidative decarboxylation of branched-chain keto acids.

@article{May1980EffectsOD,
  title={Effects of diabetes on oxidative decarboxylation of branched-chain keto acids.},
  author={M. May and V. Mancusi and R. Aftring and M. Buse},
  journal={The American journal of physiology},
  year={1980},
  volume={239 3},
  pages={
          E215-22
        }
}
  • M. May, V. Mancusi, +1 author M. Buse
  • Published 1980
  • Chemistry, Medicine
  • The American journal of physiology
  • Oxidative decarboxylation is the first irreversible step in the degradation of leucine. The effect of streptozotocin diabetes on this reaction was studied in cell-free rat liver preparations, using [1-14C]alpha-ketoisocaproate as substrate. Diabetes increased the branched-chain ketoacid dehydrogenase (BCKD) activity (per g liver or per mg protein) of homogenates, but the ratios of homogenate BCKD activity to other mitochondrial markers remained unchanged. A cytosolic branched-chain ketoacid… CONTINUE READING
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