Effects of diabetes insipidus mutations on neurophysin folding and function.

Abstract

Mechanisms underlying the pathogenicity of diabetes insipidus mutations were probed by studying their effects on the properties of bovine oxytocin-related neurophysin. The mutations G17V, DeltaE47, G57S, G57R, and C67STOP were each shown to have structural consequences that would diminish the conformational stability and folding efficiency of the precursors… (More)

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@article{Eubanks2001EffectsOD, title={Effects of diabetes insipidus mutations on neurophysin folding and function.}, author={Stephen W. Eubanks and T. L. Nguyen and Robert Deeb and Artjohn Villafania and Ahmad A Alfadhli and Esther Breslow}, journal={The Journal of biological chemistry}, year={2001}, volume={276 32}, pages={29671-80} }