Effects of diabetes and obesity on vascular reactivity, inflammatory cytokines, and growth factors.

  title={Effects of diabetes and obesity on vascular reactivity, inflammatory cytokines, and growth factors.},
  author={John Doupis and Shilpa Rahangdale and Charalambos Gnardellis and Salvador E Pena and Atul Malhotra and Aristidis Veves},
  volume={19 4},
We examined the influences of obesity and diabetes on endothelium-dependent and -independent vasodilation, inflammatory cytokines, and growth factors. We included 258 subjects, age 21-80 years in four groups matched for age and gender: 40 healthy nonobese (BMI <30 kg·m(-2)) nondiabetic subjects, 76 nonobese diabetic patients, 37 obese (BMI >30) nondiabetic subjects, and 105 obese (BMI >30) diabetic patients. The flow-mediated dilation (FMD, endothelium-dependent) and nitroglycerin-induced… CONTINUE READING
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