Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver.

@article{Ratnam2006EffectsOD,
  title={Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver.},
  author={Shobhitha Ratnam and Enoka P. Wijekoon and Beatrice Hall and Timothy A. Garrow and Margaret E Brosnan and John T Brosnan},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2006},
  volume={290 5},
  pages={
          E933-9
        }
}
Elevation of plasma homocysteine levels has been recognized as an independent risk factor for the development of cardiovascular disease, a major complication of diabetes. Plasma homocysteine reflects a balance between its synthesis via S-adenosyl-L-methionine-dependent methylation reactions and its removal through the transmethylation and the transsulfuration pathways. Betaine-homocysteine methyltransferase (BHMT, EC 2.1.1.5) is one of the enzymes involved in the remethylation pathway. BHMT, a… 
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