Effects of dextran and pentoxifylline on hemorrhagic shock-induced P-selectin expression.

@article{Akgr1999EffectsOD,
  title={Effects of dextran and pentoxifylline on hemorrhagic shock-induced P-selectin expression.},
  author={Feza Miraç Akg{\"u}r and Gazi B. Zibari and John C. McDonald and Dr. D. Neil Granger and Mark J. F. Brown},
  journal={The Journal of surgical research},
  year={1999},
  volume={87 2},
  pages={
          232-8
        }
}
BACKGROUND Dextran and pentoxifylline have been shown to prevent leukocyte-endothelium adherence encountered after hemorrhagic shock. P-Selectin is the first endothelial cell adhesion molecule to be upregulated after an ischemic insult. We investigated the effects of resuscitation with dextran 70 and administration of pentoxifylline during resuscitation on hemorrhagic shock-induced P-selectin expression. MATERIAL AND METHODS Hemorrhagic shock was induced in C57BL/6 mice by withdrawing blood… CONTINUE READING
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