Effects of dexmedetomidine on systemic and coronary hemodynamics in the anesthetized dog.

@article{Flacke1993EffectsOD,
  title={Effects of dexmedetomidine on systemic and coronary hemodynamics in the anesthetized dog.},
  author={Werner Flacke and J W Flacke and B. C. Bloor and D F McIntee and Mark Sagan},
  journal={Journal of cardiothoracic and vascular anesthesia},
  year={1993},
  volume={7 1},
  pages={41-9}
}
In addition to central effects, which are the basis of their use in anesthesiology, alpha 2-adrenergic agonists have direct peripheral cardiovascular effects. Dexmedetomidine (DM) has been found to depress cardiac function in dogs, even after autonomic denervation. The present experiments evaluated the effects of DM on coronary flow, myocardial oxygen extraction, and cardiac function in intact, open chest dogs under enflurane anesthesia. Heart rate (HR), mean arterial pressure (MAP), left… CONTINUE READING
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