Effects of dexamethasone on rhinovirus infection in cultured human tracheal epithelial cells.

@article{Suzuki2000EffectsOD,
  title={Effects of dexamethasone on rhinovirus infection in cultured human tracheal epithelial cells.},
  author={T. Suzuki and M. Yamaya and Kiyohisa Sekizawa and Norihiro Yamada and Katsutoshi Nakayama and Satoshi Ishizuka and Masato Kamanaka and T Morimoto and Yoshio Numazaki and Hidetada Sasaki},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2000},
  volume={278 3},
  pages={
          L560-71
        }
}
  • T. Suzuki, M. Yamaya, +7 authors H. Sasaki
  • Published 1 March 2000
  • Biology, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
To examine the effects of glucocorticoid on rhinovirus (RV) infection, primary cultures of human tracheal epithelial cells were infected with either RV2 or RV14. Viral infection was confirmed by demonstrating that viral RNA in infected cells and viral titers of supernatants and lysates from infected cells increased with time. RV14 infection upregulated the expression of mRNA and protein of intercellular adhesion molecule-1 (ICAM-1), the major RV receptor, on epithelial cells, and it increased… 
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41 Citations

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Erythromycin inhibits rhinovirus infection in cultured human tracheal epithelial cells.
TLDR
The results suggest that erythromycin inhibits infection by the major RV subgroup by reducing ICAM-1 and infection by both RV subgroups by blocking the RV RNA entry into the endosomes.
Carbocisteine inhibits rhinovirus infection in human tracheal epithelial cells
The aim of the study was to examine the effects of a mucolytic drug, carbocisteine, on rhinovirus (RV) infection in the airways. Human tracheal epithelial cells were infected with a major-group RV,…
Ambroxol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells
TLDR
The results suggest that ambroxol may modulate airway inflammation by reducing the production of cytokines in rhinovirus infection by reducing ICAM-1 and acidic endosomes via the inhibition of NF-κB activation.
Epithelial Cells in Primary Cultures of Human Tracheal Levofloxacin Inhibits Rhinovirus Infection
Effects of Rhinovirus Infection on Histamine and Cytokine Production by Cell Lines from Human Mast Cells and Basophils
TLDR
It is suggested that RV14 infection may prime the cytokine and histamine production from mast cells and basophils and may cause airway inflammation in asthma.
Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells.
Rhinovirus infects primary human airway fibroblasts and induces a neutrophil chemokine and a permeability factor
TLDR
Interactions between RV and human fibroblasts are feasible, may coordinate neutrophil chemoattraction with enhanced vascular permeability and that fibro Blasts may contribute to inflammatory responses following RV infections are suggested.
Tulobuterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells
TLDR
Tulobuterol may inhibit RV replication by reducing ICAM‐1 expression and acidic endosomes and modulate airway inflammation during RV replication and inhibitory effects of LABAs on the replication of rhinovirus (RV).
The proton pump inhibitor lansoprazole inhibits rhinovirus infection in cultured human tracheal epithelial cells.
Increased rhinovirus replication in nasal mucosa cells in allergic subjects is associated with increased ICAM‐1 levels and endosomal acidification and is inhibited by L‐carbocisteine
TLDR
The increased RV14 replication observed in HNE cells from allergic subjects might be partly associated with enhanced ICAM‐1 expression and decreased endosomal pH through NF‐κB activation, and modulate airway inflammation caused by RV infection in allergic subjects.
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References

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