Effects of dexamethasone on carnitine metabolism in liver and extrahepatic tissues

@article{French1985EffectsOD,
  title={Effects of dexamethasone on carnitine metabolism in liver and extrahepatic tissues},
  author={Timothy John French and A W Good and T. Norman Palmer and Mary C. Sugden},
  journal={Bioscience Reports},
  year={1985},
  volume={5},
  pages={729-734}
}
The in vivo effects of dexamethasone administration on liver and extrahepatic tissue carnitine concentrations were assessed in 48-h-starved rats. In heart and kidney, but not in liver, dexamethasone significantly increased total carnitine concentration. Acute (2.5 h) treatment with 2-tetradecylglycidate (TDG), a specific inhibitor of carnitine palmitoyl transferase 1, not only increased total hepatic carnitine concentrations, but also permitted an effect of dexamethasone (a further increase in… 
View on Springer
bioscirep.org
1 Citations

One Citation

The pharmacology of carnitine.

The administration of cami­ tine as a pharmacological agent in various situations is viewed as derivative of its role in intermediary metabolism, generally related to fatty acid metabolism.

References

SHOWING 1-10 OF 10 REFERENCES

Liver carnitine metabolism after partial hepatectomy in the rat

Transport of L-carnitine induced by prednisolone in an established cell line (CCL 27). A possible explanation of the therapeutic effect of glucocorticoids in muscular carnitine deficiency syndrome.

Properties of carnitine transport in rat kidney cortex slices.

  • P. HuthA. Shug
  • Biology, Computer Science
    Biochimica et biophysica acta
  • 1980

Carnitine metabolism and deficiency syndromes.

Progress has been made in defining and classifying the carnitine deficiency syndromes and recent efforts in basic and clinical research have provided important clues about the molecular causes of these syndrome.

Carnitine--metabolism and functions.

The only firmly established function of carnitine is its function as a carrier of activated fatty acids and activated acetate across the inner mitochondrial membrane, and the regulation of its synthesis is still incompletely understood.

Hormonal regulation of hepatic gluconeogenesis.

Carnitine metabolism in the fasting rat.

Beta - oxidation of fatty acids : relative contribution of initoehondria and peroxisomes

  • 1981

Beta-oxidation of fatty acids: relative contribution

  • J. Biol
  • 1980

Research lettersLiver carnitine metabolism after partial hepatectomy in the rat: Effects of nutritional status and inhibition of carnitine palmitoyltransferase

  • 1985