Effects of dexamethasone administration on insulin resistance and components of insulin signaling and glucose metabolism in equine skeletal muscle.

@article{Tiley2008EffectsOD,
  title={Effects of dexamethasone administration on insulin resistance and components of insulin signaling and glucose metabolism in equine skeletal muscle.},
  author={Heather A Tiley and Raymond J. Geor and L Mccutcheon},
  journal={American journal of veterinary research},
  year={2008},
  volume={69 1},
  pages={51-8}
}
OBJECTIVE To determine the effects of dexamethasone treatment on selected components of insulin signaling and glucose metabolism in skeletal muscle obtained from horses before and after administration of a euglycemic-hyperinsulinemic clamp (EHC). ANIMALS 6 adult Standardbreds. PROCEDURES In a balanced crossover study, horses received either dexamethasone (0.08 mg/kg, IV, q 48 h) or an equivalent volume of saline (0.9% NaCl) solution, IV, for 21 days. A 2-hour EHC was administered for… CONTINUE READING

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