Effects of dexamethasone, administered for growth promoting purposes, upon the hepatic cytochrome P450 3A expression in the veal calf.

@article{Cantiello2009EffectsOD,
  title={Effects of dexamethasone, administered for growth promoting purposes, upon the hepatic cytochrome P450 3A expression in the veal calf.},
  author={Michela Cantiello and Mery Giantin and Monica Carletti and Rosa Maria Lopparelli and Francesca Capolongo and Fr{\'e}d{\'e}ric Lasserre and Enrico Bollo and C Nebbia and Pascal G. P. Martin and Thierry Pineau and Mauro Dacasto},
  journal={Biochemical pharmacology},
  year={2009},
  volume={77 3},
  pages={
          451-63
        }
}
Dexamethasone (DEX) exerts its known anti-inflammatory and immunosuppressant activities through the interaction with the glucocorticoid receptor (GR). In human liver, DEX is metabolized by cytochrome P450 3A (CYP3A); moreover, it is among those xenobiotics which induce CYP3A itself. The transcriptional regulation of CYP3A involves GR and nuclear receptors (NRs). In cattle, DEX is used at low dosages as a growth promoter; besides, CYP3A is expressed in the liver. In the present study, the… CONTINUE READING
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