Effects of development and thyroid hormone on K+ currents and K+ channel gene expression in rat ventricle.

@article{Wickenden1997EffectsOD,
  title={Effects of development and thyroid hormone on K+ currents and K+ channel gene expression in rat ventricle.},
  author={Alan D. Wickenden and Roger Kaprielian and Thomas G. Parker and Owen T.G. Jones and Peter Backx},
  journal={The Journal of physiology},
  year={1997},
  volume={504 ( Pt 2)},
  pages={271-86}
}
1. In rat heart, three K+ channel genes that encode inactivating transient outward (ITO)-like currents are expressed. During development the predominant K+ channel mRNA species switches from Kv1.4 to Kv4.2 and Kv4.3. However, no functional correlate of this isoform switch has been reported. We investigated action potential characteristics and ITO in cultured neonatal rat ventricular myocytes and adult rat hearts. We further examined whether the changes in K+ channel gene expression and the… CONTINUE READING

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