Effects of desloratadine, diphenhydramine, and placebo on driving performance and psychomotor performance measurements

@article{Vuurman2004EffectsOD,
  title={Effects of desloratadine, diphenhydramine, and placebo on driving performance and psychomotor performance measurements},
  author={E. F. P. M. Vuurman and G. H. Rikken and Nienke Muntjewerff and F. de Halleux and Johannes Gerardus Ramaekers},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={60},
  pages={307-313}
}
First-generation antihistamines taken for relief of allergic rhinitis are sedating and pose potential risks for those driving a car or operating machinery. Desloratadine is a potent, selective, histamine H1-receptor antagonist that does not easily cross the blood–brain barrier. It is nonsedating at therapeutic doses and should not affect driving or psychomotor performance. This study compared the acute effects of desloratadine with diphenhydramine (active control) and placebo on the performance… CONTINUE READING
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