Effects of dermorphin on gastrointestinal transit in rats.

@article{Broccardo1982EffectsOD,
  title={Effects of dermorphin on gastrointestinal transit in rats.},
  author={Maria Broccardo and Giovanna Improta and M Nargi and Pietro Melchiorri},
  journal={Regulatory peptides},
  year={1982},
  volume={4 2},
  pages={91-6}
}
The effects of subcutaneous (s.c.) and intracerebroventricular (i.c.v.) injections of dermorphin on gastric emptying and intestinal transit were studied in rats. Dermorphin injected i.c.v. delayed gastric emptying and this effect was dose-dependent. I.c.v. injections of dermorphin also inhibited intestinal transit but a dose level 5 to 10 times higher than that active on gastric emptying was required. Subcutaneous injections of dermorphin also inhibited gastrointestinal transit but inhibition… CONTINUE READING