Effects of deoxycholate on human colon cancer cells: apoptosis or proliferation.

@article{Milovic2002EffectsOD,
  title={Effects of deoxycholate on human colon cancer cells: apoptosis or proliferation.},
  author={Vladan Milovic and Inga C. Teller and Dominik Faust and Wolfgang F. Caspary and Juergen Stein},
  journal={European journal of clinical investigation},
  year={2002},
  volume={32 1},
  pages={29-34}
}
BACKGROUND Deoxycholic acid has long been attributed as a tumour promoter in the colon. It exerts its growth-related actions in a phorbol ester-like manner, by stimulating protein kinase C. The aim of this study was to investigate the effect of deoxycholic acid on proliferation and apoptosis in the colon, by exposing colon cancer cells to it in increasing concentrations. METHODS Human colon cancer cells (Caco-2 and HT-29) were treated with deoxycholate or its two structural isomers, 3-beta-12… CONTINUE READING

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