Effects of delta-opioid receptor stimulation and inhibition on hippocampal survival in a rat model of forebrain ischaemia.

@article{Iwata2007EffectsOD,
  title={Effects of delta-opioid receptor stimulation and inhibition on hippocampal survival in a rat model of forebrain ischaemia.},
  author={Masato Iwata and Satoki Inoue and Masahiko Kawaguchi and Mitsutoshi Nakamura and Noboru Konishi and Hitoshi Furuya},
  journal={British journal of anaesthesia},
  year={2007},
  volume={99 4},
  pages={538-46}
}
BACKGROUND It has been reported that delta-opioid (DOP) receptor agonists may be neuroprotective in the central nervous system. However, the DOP agonist [d-Ala(2), d-Leu(5)]enkephalin (DADLE) does not produce neuroprotection in severe forebrain ischaemia. The aim of this study was to examine the effects of DADLE on hippocampal neurone survival against less severe forebrain ischaemia. METHODS Intraperitoneal injection of DADLE (0 or 16 mg kg(-1)) in male Sprague-Dawley rats was performed 30… CONTINUE READING

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D-Ala2, D-Leu5]enkephalin does not provide neuroprotection in the hippocampus in rats subjected to forebrain ischemia

  • AK Baker, TF Meert
  • Neurosci Lett
  • 2007

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