Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells.

@article{Chun2003EffectsOD,
  title={Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells.},
  author={Kyung Hee Chun and Jerome W. Kosmeder and Shihua Sun and John M Pezzuto and Reuben Lotan and Waun Ki Hong and Ho-young Lee},
  journal={Journal of the National Cancer Institute},
  year={2003},
  volume={95 4},
  pages={
          291-302
        }
}
BACKGROUND Because lung cancer is the leading cause of cancer-related death, new approaches for preventing and controlling the disease are needed. Chemoprevention approaches are both feasible and effective. We evaluated the potential of deguelin, a natural plant product, as a lung cancer chemopreventive agent and investigated its mechanism of action. METHODS The effects of deguelin on proliferation and apoptosis of normal, premalignant, and malignant human bronchial epithelial (HBE) cells… CONTINUE READING

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