Effects of deferoxamine on intracerebral hemorrhage-induced brain injury in aged rats.

@article{Okauchi2009EffectsOD,
  title={Effects of deferoxamine on intracerebral hemorrhage-induced brain injury in aged rats.},
  author={Masanobu Okauchi and Y -J. Hua and Richard F. Keep and Lewis Morgenstern and Guohua Xi},
  journal={Stroke},
  year={2009},
  volume={40 5},
  pages={1858-63}
}
BACKGROUND AND PURPOSE Deferoxamine (DFX) reduces brain edema, neuronal death, and neurological deficits after intracerebral hemorrhage (ICH) in young rats. In the present study, we investigated whether DFX is effective on brain injury after ICH in aged rats and examined dose dependency. METHODS Male Fischer 344 rats (18 months old) had an intracaudate injection of 100 microL autologous whole blood and were treated with different doses of DFX (10, 50, and 100 mg/kg) or vehicle 2 and 6 hours… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Similar Papers

Loading similar papers…