Effects of decreased respiratory frequency on ventilator-induced lung injury.

@article{Hotchkiss2000EffectsOD,
  title={Effects of decreased respiratory frequency on ventilator-induced lung injury.},
  author={John R. Hotchkiss and Llu{\'i}s Blanch and Gaston Murias and Alexander Bernard Adams and Don A Olson and O. Douglas Wangensteen and Perry H. Leo and John J. Marini},
  journal={American journal of respiratory and critical care medicine},
  year={2000},
  volume={161 2 Pt 1},
  pages={463-8}
}
To determine if decreased respiratory frequency (ventilatory rate) improves indices of lung damage, 17 sets of isolated, perfused rabbit lungs were ventilated with a peak static airway pressure of 30 cm H(2)O. All lungs were randomized to one of three frequency/peak pulmonary artery pressure combinations: F20P35 (n = 6): ventilatory frequency, 20 breaths/min, and peak pulmonary artery pressure, 35 mm Hg; F3P35 (n = 6), ventilatory frequency, 3 breaths/min, and peak pulmonary artery pressure of… CONTINUE READING