Effects of decellularized matrices derived from periodontal ligament stem cells and SHED on the adhesion, proliferation and osteogenic differentiation of human dental pulp stem cells in vitro.

@article{Heng2016EffectsOD,
  title={Effects of decellularized matrices derived from periodontal ligament stem cells and SHED on the adhesion, proliferation and osteogenic differentiation of human dental pulp stem cells in vitro.},
  author={Boon Chin Heng and Shaoyue Zhu and Jianguang Xu and Changyong Yuan and Ting Gong and Cheng Zhang},
  journal={Tissue & cell},
  year={2016},
  volume={48 2},
  pages={133-43}
}
A major bottleneck to the therapeutic applications of dental pulp stem cells (DPSC) are their limited proliferative capacity ex vivo and tendency to undergo senescence. This may be partly due to the sub-optimal in vitro culture milieu, which could be improved by an appropriate extracellular matrix substratum. This study therefore examined decellularized matrix (DECM) from stem cells derived from human exfoliated deciduous teeth (SHED) and periodontal ligament stem cells (PDLSC), as potential… CONTINUE READING
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