Effects of cytoplasmic and luminal pH on Ca(2+) release channels from rabbit skeletal muscle.

@article{Laver2000EffectsOC,
  title={Effects of cytoplasmic and luminal pH on Ca(2+) release channels from rabbit skeletal muscle.},
  author={Derek R. Laver and Kevin Richard Eager and L Taoube and Geoff Lamb},
  journal={Biophysical journal},
  year={2000},
  volume={78 4},
  pages={
          1835-51
        }
}
Ryanodine receptor (RyR)-Ca(2+) release channels from rabbit skeletal muscle were incorporated into lipid bilayers. The effects of cytoplasmic and luminal pH were studied separately over the pH range 5-8, using half-unit intervals. RyR activity (at constant luminal pH of 7.5) was inhibited at acidic cytoplasmic pH, with a half-inhibitory pH (pH(I)) approximately 6.5, irrespective of bilayer potential and of whether the RyRs were activated by cytoplasmic Ca(2+) (50 microM), ATP (2 or 5 mM), or… CONTINUE READING
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