Effects of cytokines on the pituitary-adrenal axis in cancer patients.

  title={Effects of cytokines on the pituitary-adrenal axis in cancer patients.},
  author={W E Nolten and David Goldstein and Mary J. Lindstrom and Michael McKenna and Ian Carlson and Donald L. Trump and Juergen Schiller and Ernest C. Borden and Edward N. Ehrlich},
  journal={Journal of interferon research},
  volume={13 5},
Cytokines, which include interferons (IFNs), interleukins (ILs), and tumor necrosis factor (TNF), are immunoregulatory proteins produced by lymphocytes and inflammatory cells. Several cytokines, most noteworthy IFNs and ILs, stimulate glucocorticoid secretion. In this study, the effects of variable doses and repetitive administration of IFNs and TNF on secretion of pituitary hormones and cortisol were measured. Patients were given for a period of 15 days on alternating days injections of IFN… CONTINUE READING


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