Effects of cytokines on platelet production from blood and marrow CD34+ cells.

@article{Norol1998EffectsOC,
  title={Effects of cytokines on platelet production from blood and marrow CD34+ cells.},
  author={Francoise Norol and Natacha Vitrat and E Cramer and Jason Guichard and Samuel A Burstein and William Vainchenker and Najet Debili},
  journal={Blood},
  year={1998},
  volume={91 3},
  pages={830-43}
}
The late stages of megakaryocytopoiesis, consisting of the terminal processes of cytoplasmic maturation and platelet shedding, remain poorly understood. A simple liquid culture system using CD34+ cells in serum-free medium has been developed to study the regulation of platelet production in vitro. Platelets produced in vitro were enumerated by flow cytometry. A truncated form of human Mpl-Ligand conjugated to polyethylene glycol (PEG-rHuMGDF) played a crucial role in both proplatelet formation… CONTINUE READING

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