Effects of cyproheptadine, reserpine, and synthetic corticotropin-releasing factor on pituitary glands from patients with Cushing's disease.

@article{Suda1983EffectsOC,
  title={Effects of cyproheptadine, reserpine, and synthetic corticotropin-releasing factor on pituitary glands from patients with Cushing's disease.},
  author={Takane Suda and Fumiko Tozawa and Takashi Mouri and Atsushi Sasaki and Tamotsu Shibasaki and Hiroshi Demura and Kazuo Shizume},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1983},
  volume={56 6},
  pages={1094-9}
}
Direct effects of cyproheptadine, reserpine, synthetic ovine corticotropin-releasing factor (CRF), dexamethasone, and lysine-8-vasopressin (LVP) on the secretion of immunoreactive ACTH and beta-endorphin from the adenoma and the nonadenomatous tissue of patients with Cushing's disease were examined using a superfusion system. Cyproheptadine and reserpine (10(-9)-10(-7) M of each) suppressed immunoreactive ACTH and beta-endorphin secretion from both tissues. CRF (10(10)-10(7) M) stimulated the… CONTINUE READING
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