Effects of cyclosporine A on skeletal muscle mitochondrial respiration and endurance time in rats.

@article{Mercier1995EffectsOC,
  title={Effects of cyclosporine A on skeletal muscle mitochondrial respiration and endurance time in rats.},
  author={Jean Mercier and James F. Hokanson and George A. Brooks},
  journal={American journal of respiratory and critical care medicine},
  year={1995},
  volume={151 5},
  pages={1532-6}
}
We investigated the effects of 14 d of cyclosporine A (CsA) administration on skeletal muscle mitochondrial respiration and submaximal running endurance time in rats. Eight experimental (CsA) and eight control rats followed a 14-d feeding protocol of CsA (20 mg/kg/d) oral administration or placebo. Submaximal endurance exercise time (EET) was measured on a treadmill on Day 13 and mitochondria were isolated from the hind limb muscles homogenate on Day 15. The results showed (1) a significant… CONTINUE READING

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