Effects of cyclosporine A and methotrexate on induction of tumour necrosis factor-alpha in rat cardiac allografts.

Abstract

Experimental and clinical studies have yet to determine the extent to which methotrexate (MTX) or cyclosporine A (CSA) treatment alone affects the expression in vivo of tumour necrosis factor-alpha (TNF alpha), a cytokine produced primarily by macrophages and believed to be directly involved in the pathogenesis of cardiac allograft rejection. In light of… (More)

Topics

Cite this paper

@article{Ciesielski1997EffectsOC, title={Effects of cyclosporine A and methotrexate on induction of tumour necrosis factor-alpha in rat cardiac allografts.}, author={Cathleen J. Ciesielski and Jie Mei and James Neton and Luca Piccinini}, journal={Transplant immunology}, year={1997}, volume={5 1}, pages={25-34} }