Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis.

@article{Hong2008EffectsOC,
  title={Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis.},
  author={Ting-Ting Hong and Jinbao Huang and Terrance D. Barrett and Benedict Robert Lucchesi},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={294 1},
  pages={H145-55}
}
This study was designed to determine the effect of inhibitors of cyclooxygenase (COX)-1, COX-2, and the nonselective COX inhibitor naproxen on coronary vasoactivity and thrombogenicity under baseline and lipopolysaccharide (LPS)-induced inflammatory conditions. We hypothesize that endothelial COX-1 is the primary COX isoform in the canine normal coronary… CONTINUE READING