Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD.

@article{Montuschi2005EffectsOC,
  title={Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD.},
  author={Paolo Montuschi and Francesco Macagno and Paola Parente and S. Daniele Valente and Libero Lauriola and Giuliano Ciappi and Sergei A. Kharitonov and Peter J Barnes and Giovanni Ciabattoni},
  journal={Thorax},
  year={2005},
  volume={60 10},
  pages={827-33}
}
BACKGROUND Leukotriene (LT) B4 concentrations are increased and prostaglandin (PG) E2 concentrations are decreased in exhaled breath condensate (EBC) in patients with chronic obstructive pulmonary disease (COPD). A study was undertaken to investigate the short term effects of cyclo-oxygenase (COX) inhibition on exhaled LTB4 and PGE2 concentrations in patients with COPD and to identify the COX isoform responsible for exhaled PGE2 production. METHODS Two studies were performed. A double blind… CONTINUE READING

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