Effects of current and former cigarette smoking on the clinical course of Crohn’s disease
@article{Cosnes1999EffectsOC, title={Effects of current and former cigarette smoking on the clinical course of Crohn’s disease}, author={Cosnes and Carbonnel and Carrat and Beaugerie and Cattan and Gendre}, journal={Alimentary Pharmacology \& Therapeutics}, year={1999}, volume={13} }
: Cigarette smoking is associated with a more severe course of Crohn’s disease, but individual factors determining this effect are poorly known and it is not clear whether smoking cessation is associated with an improvement in the disease activity.
197 Citations
Assessment of factors associated with smoking cessation at diagnosis or during follow‐up of Crohn's disease
- MedicineJournal of gastroenterology and hepatology
- 2018
The benefits and risks of smoking cessation after Crohn's disease diagnosis have not been well established and further research is needed to establish a causative factor.
Effect of oral tobacco use and smoking on outcomes of Crohn's disease in India
- Medicine, PsychologyJournal of gastroenterology and hepatology
- 2018
The study aimed to assess the association between smoking or OT and outcomes in CD and found no link between smoking and outcomes.
Systematic review with meta‐analysis: the adverse effects of tobacco smoking on the natural history of Crohn's disease
- MedicineAlimentary pharmacology & therapeutics
- 2016
Tobacco smoking is a well‐established risk factor for the development of Crohn's disease, and this may lead to a more complicated disease course. However, recent evidence suggests that many patients…
Smoking does influence disease behaviour and impacts the need for therapy in Crohn′s disease in the biologic era
- MedicineAlimentary pharmacology & therapeutics
- 2013
Recently, the notion that smoking may adversely affect Crohn′s disease (CD) outcomes has been challenged by the suggestion that the widespread use of immunosuppressants and anti‐TNF drugs might…
Review article: ulcerative colitis, smoking and nicotine therapy
- MedicineAlimentary pharmacology & therapeutics
- 2012
Smoking is the best‐characterised environmental association of ulcerative colitis (UC). Smoking has been observed to exert protective effects on both the development and progression of UC.
Impact of smoking on the surgical outcome of Crohn's disease: a propensity‐score matched National Surgical Quality Improvement Program analysis
- MedicineColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
- 2015
The present study addressed the specific impact of smoking on the outcome of surgery for CD with a focus on smokers with Crohn's disease.
Review article: altering the natural history of Crohn's disease – evidence for and against current therapies
- MedicineAlimentary pharmacology & therapeutics
- 2007
The natural course of Crohn's disease is characterized by flare‐ups altered with periods of remission, but major advances in treatment options over the past years have made treatment goals more ambitious and modification of the natural course has become the ultimate endpoint.
Impact of Smoking Cessation on the Clinical Course of Crohn’s Disease Under Current Therapeutic Algorithms: A Multicenter Prospective Study
- MedicineThe American Journal of Gastroenterology
- 2016
Continuing smokers have more disease relapses, and patients who quit smoking have a similar relapse incidence compared with nonsmokers, as evaluated in a multicenter prospective cohort study.
References
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Patients who smoke, particularly women and heavy smokers, run a high risk of developing severe disease and immunosuppressive therapy neutralizes the influence of smoking on surgical rates.
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Data suggest that the course of Crohn's disease is less favourable in smokers than in non-smokers, as measured by the risk of surgery.
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The course of Crohn's disease analysed in different ways was unfavourable for smokers, especially heavy smokers, and patients with Crohn't disease should be dissuaded from smoking.
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A meta-analysis of the role of smoking in inflammatory bowel disease
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There is no justification for health care providers to change the Surgeon General's recommendations on smoking or tobacco use for ulcerative colitis patients specifically and a review of the literature, meta-analysis of selected studies, and assessment of causality criterion suggest that not smoking and ulceratives colitis and smoking and Crohn's disease are consistent with a causal relationship.
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The study suggests that (a) smoking protects the colon from inflammation and (b) is associated with more active disease in Crohn's disease.
Inflammatory Bowel Disease: Is There Any Relation Between Smoking Status and Disease Presentation?
- Medicine
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The study suggests that (a) smoking protects the colon from inflammation and (b) smoking is associated with more active disease in Crohn's disease.